Heike Endepols

Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity

This study shows that autophagy regulator ATG5 protects cerebellar Purkinje cells by maintaining glycolytic activity, preventing neurodegeneration through regulation of glucose transporter 2.

Sulfite oxidase deficiency causes persulfidation loss and H2S release

This study shows that SOX deficiency leads to persulfidation loss and increased H2S release, with thiosulfate accumulation and metabolic rewiring in a mouse model.

TgF344-AD rat model of Alzheimer's disease: spatial disorientation and asymmetry in hemispheric neurodegeneration

The paper investigates spatial disorientation and hemispheric neurodegeneration in TgF344-AD rats, finding asymmetrical neurodegeneration and impaired spatial memory.

Preserved striatal innervation and motor function despite severe loss of nigral dopamine neurons following mitochondrial dysfunction induced by mtDNA mutations

This study shows that mice with severe loss of nigral dopamine neurons due to mtDNA mutations still maintain motor function through preserved striatal innervation.

Model-based prediction of muscarinic receptor function from auditory mismatch negativity responses

This paper uses dynamic causal models to infer muscarinic receptor function from EEG data in rats, showing graded effects and predictive validity across pharmacological conditions.

A common molecular mechanism for cognitive deficits and craving in alcoholism

This study identifies a common molecular mechanism involving mGluR2 dysfunction linking cognitive deficits and alcohol craving, and develops a biomarker for targeted interventions.