Author

Fred W. Alt

Howard Hughes Medical Institute

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Immunology· 1

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Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1 Organism:mouse· 1

Frequent Co-Authors

Adam Yongxin YeiD· 1 shared Camille HebertiD· 1 shared David CheniD· 1 shared Hongli HuiD· 1 shared Job DekkeriD· 1 shared Mariia MikhovaiD· 1 shared Taimor Williams· 1 shared Xin LiniD· 1 shared

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2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Adam Yongxin YeORCID

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1 paper

Recent·Most cited

Robust V(D)J Recombination in the Absence of SA1/2-mediated Chromatin Loops

Zhuo Yang, Yu Fu, Mariia Mikhova, David Chen, Camille Hebert, Adam Yongxin Ye, Xin Lin, Taimor Williams, Hongli Hu, Zhaoqing Ba, Job Dekker, Fred W. Alt

This study shows that SA1/2 are not essential for V(D)J recombination in G0/G1-arrested cells, but their absence disrupts chromatin loops and long-range Igh recombination, while Ig{kappa} recombination remains functional.

bioRxiv · Oct 11, 2026 · PreprintImmunology