Mariia Mikhova

This study shows that SA1/2 are not essential for V(D)J recombination in G0/G1-arrested cells, but their absence disrupts chromatin loops and long-range Igh recombination, while Ig{kappa} recombination remains functional.

The paper demonstrates that a human antibody heavy chain variable region exon forms a stable somatic hypermutation center (SHM-C) through interaction with 3' regulatory regions, supporting AID access and SHM in non-dividing cells.

The paper shows that a dynamic RNA hub formed by nascent switch region transcripts facilitates AID recruitment to the IgH locus, driving class switch recombination.

The paper shows Ku prevents aberrant mRNA splicing caused by intronic antisense Alu elements, which affects RNA metabolism and cell viability.