Inherited mitochondrial dysfunction triggered by OPA1 mutation impacts the sensory innervation fibre identity, functionality and regenerative potential in the cornea
Léna Meneux, Nadège Feret, Sarah Pernot, Mélissa Girard, Solange Sarkis, Alicia Caballero Megido, Mélanie Quiles, Laura Fichter, Jerome Viaralet, Christophe Hirtz, Cécile Delettre, Frederic Michon
This study shows that OPA1 mutation causes corneal innervation issues, including reduced sensitivity and impaired regeneration, despite normal epithelial function.
bioRxiv · Apr 18, 2024 · PreprintPathology