Reversible multiscale corneal sexual dimorphism orchestrates neuro-epithelial coupling and tear proteome composition
Nadège Feret, Alicia Caballero Megido, Sarah Pernot, Mélissa Girard, Marilou Decoudu, Laura Fichter, Aurore Attina, Jérôme Vialaret, Alexandre David, Vincent Daïen, Karine Loulier, Christophe Hirtz, Frédéric Michon
This study shows that sex hormones influence corneal graft rejection risk by modulating tear composition, epithelial dynamics, and sensory function, with androgen treatment reversing these sex-linked differences.
bioRxiv · Oct 2, 2025 · PreprintPhysiology