Author

G. A. Challen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

C. R. Zhang· 1 shared D. A. Fisher· 1 shared E. Eudy· 1 shared E. Krug· 1 shared H. Bjeije· 1 shared H. Celik· 1 shared H. K. Koblish· 1 shared J. Fowles· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

C. R. Zhang

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2 papers

Recent·Most cited

Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness Versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis

J. M. SanMiguel, E. Eudy, M. A. Loberg, K. A. Young, J. J. Mistry, L. S. Schwartz, T. Stearns, G. A. Challen, J. J. Trowbridge

The paper investigates how distinct TNF receptors influence mutant HSC fitness and lineage output in Dnmt3a-mutant clonal hematopoiesis, showing independent regulation of clone size and cell type production.

bioRxiv · Jul 3, 2022Cell Biology

A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms

H. Celik, E. Krug, C. R. Zhang, W. Han, N. Issa, W. K. Koh, H. Bjeije, O. Kukhar, M. Allen, T. Li, D. A. Fisher, J. Fowles, T. N. Wong, M. C. Stubbs, H. K. Koblish, , G. A. Challen

This paper introduces a humanized animal model using patient-derived xenografts to study myeloproliferative neoplasms and identify therapeutic vulnerabilities.

bioRxiv · Nov 12, 2020Cancer Biology