Author

J. J. Trowbridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

K. A. Young· 3 shared J. J. Mistry· 2 shared L. S. Schwartz· 2 shared A. Dunbar· 1 shared A. Krishnan· 1 shared A. R. Martinez Benitez· 1 shared C. R. Potts· 1 shared D. Lee· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCell Biology

K. A. Young

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Author profile →

4 papers

Recent·Most cited

Mesenchymal Stromal Cell Senescence Induced by Dnmt3a-Mutant Hematopoietic Cells is a Targetable Mechanism Driving Clonal Hematopoiesis and Initiation of Hematologic Malignancy

J. J. Mistry, K. A. Young, P. C. Diaz, I. F. Maestre, R. Levine, J. J. Trowbridge

bioRxiv · Mar 28, 2024 · PreprintCell Biology

Oncostatin M is a Master Regulator of an Inflammatory Network in Dnmt3a-Mutant Hematopoietic Stem Cells

L. S. Schwartz, K. A. Young, T. M. Stearns, N. Boyer, K. D. Mujica, J. J. Trowbridge

This study identifies Oncostatin M (OSM) as a master regulator of an inflammatory network in Dnmt3a-mutant hematopoietic stem cells, showing its role in age-associated clonal hematopoiesis.

bioRxiv · Jul 12, 2023 · PreprintCell Biology

Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness Versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis

J. M. SanMiguel, E. Eudy, M. A. Loberg, K. A. Young, J. J. Mistry, L. S. Schwartz, T. Stearns, G. A. Challen, J. J. Trowbridge

The paper investigates how distinct TNF receptors influence mutant HSC fitness and lineage output in Dnmt3a-mutant clonal hematopoiesis, showing independent regulation of clone size and cell type production.

bioRxiv · Jul 3, 2022Cell Biology

Modeling clonal evolution and oncogenic dependency in vivo in the context of hematopoietic transformation

R. L. Bowman, A. Dunbar, T. Mishra, W. Xiao, M. R. Waarts, I. Fernandez Maestre, S. E. Eisman, L. Cai, S. F. Cai, P. Sanchez Vela, S. Mowla, A. R. Martinez Benitez, Y. Park, I. S. Csete, A. Krishnan, , R. L. Levine

This study models clonal evolution and oncogenic dependency in hematopoietic transformation using reversible mutagenesis and allelic frameworks.

bioRxiv · May 18, 2022 · PreprintCancer Biology