The Lonidamine Derivative H2-Gamendazole Reduces Cyst Formation in Polycystic Kidney Disease
S. V. Sundar, X. Zhou, B. S. Magenheimer, G. A. Reif, D. P. Wallace, G. I. Georg, S. R. Jakkaraj, J. S. Tash, A. Yu, X. Li, J. P. Calvet
This study shows that H2-GMZ reduces cyst formation in ADPKD by inhibiting Cl- secretion, cell proliferation, and motility in both in vitro and in vivo models.
bioRxiv · Sep 9, 2020Pharmacology & Toxicology