Author

G. I. Georg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Majumbar· 1 shared A. Yang· 1 shared A. Yu· 1 shared B. S. Magenheimer· 1 shared D. A. Harki· 1 shared D. P. Wallace· 1 shared D. Rasmussen· 1 shared E. B. Faber· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Majumbar

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2 papers

Recent·Most cited

Development of allosteric, selective cyclin-dependent kinase 2 (CDK2) inhibitors that are negatively cooperative with cyclin binding and show potential as contraceptive agents

E. B. Faber, J. Tang, E. Roberts, S. Ganeshkumar, L. Sun, N. Wang, D. Rasmussen, A. Majumbar, K. John, A. Yang, H. Khalid, J. E. Hawkinson, N. M. Levinson, E. Schonbrunn, V. Chennathukuzhi, , G. I. Georg

This paper develops high-affinity, structurally confirmed allosteric CDK2 inhibitors that show negative cooperativity with cyclin binding and demonstrate contraceptive potential in mouse testicular explants.

bioRxiv · Jun 30, 2022 · PreprintPharmacology & Toxicology

The Lonidamine Derivative H2-Gamendazole Reduces Cyst Formation in Polycystic Kidney Disease

S. V. Sundar, X. Zhou, B. S. Magenheimer, G. A. Reif, D. P. Wallace, G. I. Georg, S. R. Jakkaraj, J. S. Tash, A. Yu, X. Li, J. P. Calvet

This study shows that H2-GMZ reduces cyst formation in ADPKD by inhibiting Cl- secretion, cell proliferation, and motility in both in vitro and in vivo models.

bioRxiv · Sep 9, 2020Pharmacology & Toxicology