Cancer BiologyBlood AdvancesPeer-reviewed
Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia
L. Cao, G. A. Ruiz Buendia, N. Fournier…·F. Radtke
The paper identifies PIK3R1 loss as a resistance mechanism to NOTCH inhibition in T-ALL and shows CDK4/6 inhibitors synergize with NOTCH inhibitors.
DOI 10.1182/bloodadvances.2023010380