Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia
L. Cao, G. A. Ruiz Buendia, N. Fournier, Y. Liu, F. Armand, R. Hamelin, M. Pavlou, F. Radtke
The paper identifies PIK3R1 loss as a resistance mechanism to NOTCH inhibition in T-ALL and shows CDK4/6 inhibitors synergize with NOTCH inhibitors.
Blood Advances · Oct 24, 2023Peer-reviewedCancer Biology