Identification of extracellular membrane protein ENPP3 as a major cGAMP hydrolase, cementing cGAMP's role as an immunotransmitter
R. Mardjuki, S. Wang, J. Carozza, G. Abhiraman, X. Lyu, L. Li
The paper identifies ENPP3 as a second cGAMP hydrolase, showing it regulates cGAMP levels and impacts cancer immunity.
bioRxiv · Jan 12, 2024 · PreprintBiochemistry