X. Lyu

Structural Basis for the Activation of Proteinase-Activated Receptors (PARs) by Endogenous Ligands

This study presents structural insights into PAR1 and PAR2 activation by endogenous ligands, revealing a novel mechanism and potential targets for therapeutic development.

The microtubule regulator EFA-6 forms spatially restricted cortical foci dependent on its intrinsically disordered region and interactions with tubulins

A PTER-dependent pathway of taurine metabolism linked to energy balance

This study identifies PTER as the taurine N-acetyltransferase/hydrolase, showing its role in regulating N-acetyltaurine levels and linking it to energy balance and metabolic phenotypes.

Identification of extracellular membrane protein ENPP3 as a major cGAMP hydrolase, cementing cGAMP's role as an immunotransmitter

The paper identifies ENPP3 as a second cGAMP hydrolase, showing it regulates cGAMP levels and impacts cancer immunity.

Neutrophil Extracellular Traps Drive a skin-kidney inflammatory axis in UVB-Irradiated Lupus-Prone Mice

This study identifies a skin-kidney inflammatory axis driven by UVB-induced NETosis in lupus-prone mice, highlighting PKC and CXCR4 as therapeutic targets.

Lac-Phe mediates the anti-obesity effect of metformin

This study identifies Lac-Phe as a mediator of metformin's anti-obesity effects through experiments in mice and human cohorts.

Surface-engineered extracellular vesicles to modulate antigen-specific T cell expansion for cancer immunotherapy

The paper develops antigen-presenting extracellular vesicles (AP-EVs) engineered to enhance T cell expansion and anticancer immunity through combined immunotherapy.

A class of secreted mammalian peptides with potential to expand cell-cell communication

The paper identifies a new class of secreted mammalian peptides, capped peptides, which may regulate cell-cell communication through post-translational modifications.

ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway

This study identifies ENPP1 as an innate immune checkpoint that suppresses the cGAMP-STING pathway, promoting tumor growth and metastasis, and shows that inhibiting its cGAMP hydrolase activity enhances cancer immunity.

CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels

The paper identifies CYP4F2 as a human-specific genetic determinant of plasma N-acyl amino acid levels and shows its role in metabolic diversification.

Quantitative proteomics combined with network pharmacology analysis unveils the biological basis of Schisandrin B in treating diabetic nephropathy

This study identifies the mechanisms of Schisandrin B in treating diabetic nephropathy using network pharmacology and quantitative proteomics in rats.

3D co-culture of macrophages and fibroblasts in a sessile drop chip for unveiling the role of macrophages in skin wound-healing

This study develops a sessile drop chip to create 3D spheroids of fibroblasts and macrophages, showing that M2 macrophages enhance fibroblast proliferation and differentiation in a wound-healing model.

From whole genome to probiotic candidates: a study of potential Lactobacillus strain selection for vaginitis treatment

This study identifies two Lactobacillus strains with probiotic properties for vaginitis treatment using genomic analysis, in vitro tests, and in vivo experiments.

The identification of two newly discovered fluorescent proteins in human glioblastoma

The paper identifies two newly discovered fluorescent proteins in human glioblastoma cells through immunofluorescence staining and validates their properties.

Chimeric mRNA based COVID-19 vaccine induces protective immunity against Omicron and Delta

This study develops a chimeric mRNA vaccine that provides broad protection against Omicron and Delta variants of SARS-CoV-2 by combining RBDs from different variants.

Directing an mRNA-LNP vaccine toward lymph nodes improves humoral and cellular immunity against SARS-CoV-2

This study develops an mRNA-LNP vaccine (STI-7264) and a lymphatic delivery device (MuVaxx) that enhance immune responses against SARS-CoV-2 with reduced dosing.

Rho Kinase regulates neutrophil NET formation that is involved in UVB-induced skin inflammation

This study shows that Rho kinase regulates neutrophil NET formation, which contributes to UVB-induced skin inflammation.

Flexible cobamide metabolism in Clostridioides (Clostridium) difficile 630 Δerm

This study investigates cobamide metabolism in C. difficile, showing its ability to use diverse cobamides and bypass cobamide-dependent processes, with implications for disease treatment.