Author

G. Avecilla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3

Signature Assays, Organisms & Methods

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Organism:yeast· 2 Approach:Bayesian inference· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:long-read sequencing· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

D. Gresham· 3 shared J. Chuong· 2 shared N. Brandt· 2 shared Y. Ram· 2 shared F. Abdul-Rahman· 1 shared F. Li· 1 shared G. J. Sherlock· 1 shared G. Sethia· 1 shared

Activity by Year

2018-2024 · peak 1/yr

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3 shared papersEvolutionary Biology

D. Gresham

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3 papers

Recent·Most cited

Template switching during DNA replication is a prevalent source of adaptive gene amplification

J. Chuong, N. Ben Nun, I. Suresh, J. Matthews, T. De, G. Avecilla, F. Abdul-Rahman, N. Brandt, Y. Ram, D. Gresham

The paper investigates how genomic architecture influences the formation and fitness of adaptive copy number variants (CNVs) in yeast, finding that template switching during DNA replication is a common mechanism for CNV generation.

bioRxiv · May 3, 2024Evolutionary Biology

Simulation-based inference of evolutionary parameters from adaptation dynamics using neural networks

G. Avecilla, J. Chuong, F. Li, G. J. Sherlock, D. Gresham, Y. Ram

The paper estimates beneficial mutation rates and fitness effects using simulation-based Bayesian inference on CNV dynamics in yeast.

bioRxiv · Sep 30, 2021 · PreprintEvolutionary Biology

Single-cell copy number variant detection reveals the dynamics and diversity of adaptation

S. Lauer, G. Avecilla, P. Spealman, G. Sethia, N. Brandt, S. Levy, D. Gresham

This study detects single-cell copy number variants (CNVs) in evolving populations and identifies ODIRA as a common mechanism for gene amplification.

bioRxiv · Jul 31, 2018Evolutionary Biology