G. J. Sherlock

Analysis and culturing of the prototypic crAssphage reveals a phage-plasmid lifestyle

This study characterizes the crAssphage lifestyle as a phage-plasmid, demonstrating its persistence in the gut microbiome without causing host lysis or chromosomal integration.

Spindle architecture constrains karyotype in budding yeast

The paper shows that spindle architecture limits karyotype evolution in budding yeast by demonstrating that chromosome fusions are tolerated until a critical centromere number is reached.

Far From Home: Evolution of haploid and diploid populations reveals common, strong, and variable pleiotropic effects in non-home environments

The paper evolves haploid and diploid yeast populations in different environments and finds common, unpredictable pleiotropic effects of adaptive mutations in non-home environments.

Simulation-based inference of evolutionary parameters from adaptation dynamics using neural networks

The paper estimates beneficial mutation rates and fitness effects using simulation-based Bayesian inference on CNV dynamics in yeast.

Acquisition, transmission and strain diversity of human gut-colonizing crAss-like phages

The paper analyzes gut metagenomic data to study the acquisition, transmission, and strain diversity of crAss-like phages in mother-infant pairs and fecal microbiota transplantation recipients.

The dynamics of adaptive genetic diversity during the early stages of clonal evolution

This study investigates genetic diversity dynamics in clonally evolving populations, finding predictable early increases followed by a diversity crash due to highly-fit double mutants.