DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress in triple-negative breast cancer
R. Moreno, S. Banerjee, A. W. Jackson, J. Quinn, G. Baillie, J. E. Dixon, A. T. Dinkova-Kostova, J. Edwards, L. de la Vega
This study identifies DYRK2 as a kinase that phosphorylates HSF1, enhancing its activity and promoting resistance to proteotoxic stress in TNBC, with implications for therapeutic targeting.
bioRxiv · Jun 2, 2019Cancer Biology