USP8 inhibition promotes Parkin-independent mitophagy in the Drosophila brain and in human neurons
S. Mauri, G. Bernardo, A. Martinez, M. Favaro, M. Trevisan, G. Cobraiville, M. Fillet, F. Caicci, A. J. Whitworth, E. Ziviani
This study shows that USP8 inhibition increases Parkin-independent mitophagy in Drosophila and human neurons by reducing USP8 levels, suggesting a new mitophagic pathway.
bioRxiv · Jan 30, 2023 · PreprintCell Biology