Author

A. J. Whitworth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:Drosophila· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Sanchez-Martinez· 2 shared A. Terriente-Felix· 2 shared J. J. Lee· 2 shared A. Knebel· 1 shared A. Martinez· 1 shared A. Martinez Zarate· 1 shared A. Shaw· 1 shared A. Vagnoni· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCell Biology

A. Sanchez-Martinez

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Author profile →

6 papers

Recent·Most cited

Regulation of Human PINK1 ubiquitin kinase by Serine167, Serine228 and Cysteine412 phosphorylation

A. Waddell, H. Ojha, S. Agarwal, C. Clarke, A. Terriente-Felix, H. Zhou, P. Kakade, A. Knebel, A. Shaw, R. Gourlay, J. Varghese, R. Soares, R. Toth, T. Macartney, P. Eyers, , M. Muqit

This study identifies phosphorylation sites in hPINK1 that regulate its activation and ubiquitin interaction, revealing a novel inhibitory mechanism involving pCys412.

bioRxiv · Mar 31, 2023 · PreprintBiochemistry

USP8 inhibition promotes Parkin-independent mitophagy in the Drosophila brain and in human neurons

S. Mauri, G. Bernardo, A. Martinez, M. Favaro, M. Trevisan, G. Cobraiville, M. Fillet, F. Caicci, A. J. Whitworth, E. Ziviani

This study shows that USP8 inhibition increases Parkin-independent mitophagy in Drosophila and human neurons by reducing USP8 levels, suggesting a new mitophagic pathway.

bioRxiv · Jan 30, 2023 · PreprintCell Biology

Parkin drives pS65-Ub turnover independently of canonical autophagy in Drosophila

J. L. Usher, J. J. Lee, A. Sanchez-Martinez, A. J. Whitworth

The paper investigates the role of the Pink1-Parkin pathway in mitochondrial quality control in Drosophila, finding that it promotes mitochondrial turnover independently of canonical autophagy.

bioRxiv · Jun 10, 2021Cell Biology

Decreasing pdzd8-mediated mitochondrial-ER contacts in neurons improves fitness by increasing mitophagy

V. L. Hewitt, L. Miller-Fleming, S. Andreazza, F. Mattedi, J. Prudent, F. Polleux, A. Vagnoni, A. J. Whitworth

This study shows reducing pdzd8-mediated mitochondrial-ER contacts in neurons improves fitness and lifespan by enhancing mitophagy in Drosophila.

bioRxiv · Nov 14, 2020Cell Biology

Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes

A. Terriente-Felix, E. L. Wilson, A. J. Whitworth

This study identifies Drosophila Fwd as a pro-fission factor that promotes mitochondrial fission and suppresses Pink1/parkin mutant phenotypes.

bioRxiv · May 13, 2020Cell Biology

Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin

J. J. Lee, A. Sanchez-Martinez, A. Martinez Zarate, C. Beninca, U. Mayor, M. J. Clague, A. J. Whitworth

The paper investigates the role of PINK1 and parkin in basal mitophagy in Drosophila, finding no significant impact on basal mitophagy despite locomotor defects and dopaminergic neuron loss.

bioRxiv · Jan 12, 2018Cell Biology