Functional diversity of NLRP3 gain-of-function mutants associated with CAPS autoinflammation.
C. Cosson, R. Riou, D. Patoli, T. Niu, A. Rey, M. Groslambert, E. Chatre, O. Allatif, T. Henry, F. Venet, F. Milhavet, G. Boursier, A. Belot, Y. Jamilloux, E. Merlin, , B. F. Py
This study functionally characterizes 34 NLRP3 variants associated with CAPS, identifying functional diversity and inhibitor sensitivity, with implications for diagnosis and drug development.
bioRxiv · Sep 22, 2023 · PreprintImmunology