T. Niu

Functional diversity of NLRP3 gain-of-function mutants associated with CAPS autoinflammation.

This study functionally characterizes 34 NLRP3 variants associated with CAPS, identifying functional diversity and inhibitor sensitivity, with implications for diagnosis and drug development.

HOPE-SIM, a cryo-structured illumination fluorescence microscopy system for accurately targeted cryo-electron tomography

The paper introduces HOPE-SIM, a cryo-CLEM system that improves targeting precision for cryo-ET by integrating 3D SIM and software, achieving 150 nm correlation accuracy.

ELI trifocal microscope: A precise cryogenic fabrication system to prepare target cryo-lamellae of cells for in situ cryo-ET study

The paper introduces ELI-TriScope, a cryogenic system for precise cryo-lamella preparation, achieving 100% success in targeting HeLa cell centrosomes for cryo-ET structural analysis.

Imaging biological samples by integrated differential phase contrast (iDPC) STEM technique

This study demonstrates that iDPC-STEM provides superior contrast and structural detail in biological samples compared to conventional TEM, especially at low doses and for thick sections.

MMP12 Knockout Prevent Weight and Muscle Loss Induced by Cancer Cachexia

This study shows that MMP12 knockout prevents weight and muscle loss in ApcMin/+ mice with cancer cachexia by disrupting insulin and glycolipid metabolism.

VHUT-cryo-FIB, a method to fabricate frozen-hydrated lamella of tissue specimen for in situ cryo-electron tomography

The paper introduces VHUT-cryo-FIB, a workflow for preparing frozen-hydrated tissue lamella for cryo-ET, and demonstrates its effectiveness using rat and spinach samples.

Cryo-EM structures reveal interactions of S-OPA1 with membrane and changes upon nucleotide binding

The paper uses cryo-EM to study SOPA1's structure and conformational changes upon GTP binding, revealing its unique mechanism in mitochondrial membrane fusion.