A sensor complements the steric gate when DNA polymerase ϵ discriminates ribonucleotides.
V. Parkash, Y. Kulkarni, G. Bylund, P. Osterman, S. C. L. Kamerlin, E. Johansson
This study identifies a sensor in the finger domain of DNA polymerase ϵ that complements the steric gate in discriminating ribonucleotides from deoxyribonucleotides.
bioRxiv · Jul 1, 2023 · PreprintBiochemistry