K. Thorell

Vaccination with Helicobacter pylori attachment proteins protects against gastric cancer

This study shows that vaccination with H. pylori attachment protein BabA induces blocking antibodies that reduce gastric inflammation and prevent gastric cancer in mice.

Helicobacter pylori attachment-blocking antibodies protect against duodenal ulcer disease

The paper shows that antibodies blocking H. pylori attachment reduce chronic inflammation and duodenal ulcer risk by mimicking BabA's binding to ABO glycans.

An ancient ecospecies of Helicobacter pylori found in Indigenous populations and animal adapted lineages.

The paper identifies a new ecospecies of Helicobacter pylori, 'Hardy', found in Indigenous populations and animal-adapted lineages, with distinct genetic features and evolutionary history.

Circulation of enterotoxigenic Escherichia coli (ETEC) isolates expressing CS23 from the environment to clinical settings

This study identifies LT+STh CS23 ETEC strains circulating between polluted water and children with diarrhea in La Paz, Bolivia, highlighting the river as a reservoir for antibiotic-resistant pathogens.

Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations

This study shows H. pylori has spread repeatedly from Africa by replacing strains with deleterious mutations through migration and selection.

Genomic differentiation within East Asian Helicobacter pylori

This study identifies genomic differentiation in Helicobacter pylori across East Asia, linking specific SNPs to cancer risk and geographic adaptation.

Uneven growth of SARS-CoV-2 clones evidenced by more than 500,000 whole-genome sequences

The paper analyzes SARS-CoV-2 variant frequencies using 500,000 whole-genome sequences, finding that mutations within variants do not rise in unison, suggesting multiple distinct variants.

Serotype has a significant impact on the virulence of 7th pandemic Vibrio cholerae O1

This study shows that Inaba serotype of Vibrio cholerae O1 is less virulent than Ogawa serotype in an infant mouse model due to gene expression differences caused by the wbeT gene mutation.

The speciation and hybridization history of the genus Salmonella

This study investigates the speciation and hybridization history of Salmonella, identifying eleven phylogroups and revealing complex hybridization events that challenge traditional speciation models.

Isolates from colonic spirochaetosis in humans show high genomic divergence and carry potential pathogenic features but are not detected by 16S amplicon sequencing using standard primers for the human microbiota

The paper isolates and genomes Brachyspira species from colonic spirochaetosis cases, showing genetic diversity and potential pathogenic features, but finds standard 16S primers fail to detect them.