Author

G. C. A. da Hora

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

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Research Focus:cell signaling & trafficking· 2 Approach:mechanistic / dynamical model· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:multiome· 1

Frequent Co-Authors

J. D. M. Nguyen· 2 shared J. M. Swanson· 2 shared J. M. J. Swanson· 1 shared M. Oh· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 2 mutual co-author links

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2 shared papersBiophysics

J. D. M. Nguyen

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3 papers

Recent·Most cited

BiophysicsbioRxivAug 16, 2023

tICA-Metadynamics for Identifying Slow Dynamics in Membrane Permeation

M. Oh, G. C. A. da Hora, J. M. J. Swanson

This paper applies tICA-metadynamics to identify slow dynamics in trimethoprim permeation through a multicomponent membrane, improving convergence efficiency and correcting artifacts in collective variables.

DOI 10.1021/acs.jctc.3c00526

multiomedeep learning

𝕏 PostBluesky

BiophysicsbioRxivPreprintMay 19, 2023

Mycolactone A vs. B: Does localization or association explain isomer-specific toxicity?

J. D. M. Nguyen, G. C. A. Da Hora, J. M. Swanson

This study compares mycolactone A and B to determine why only B is cytotoxic, finding that B's stronger ER membrane association and translocon interactions explain its toxicity.

DOI 10.1101/2023.05.19.541532

mechanistic / dynamical modelprotein folding & dynamics

𝕏 PostBluesky

BiophysicsbioRxivMay 31, 2022

Can Membrane Composition Traffic Toxins? Mycolactone and Preferential Membrane Interactions

G. C. A. da Hora, J. D. M. Nguyen, J. M. Swanson

This study investigates mycolactone's preferential interactions with different membranes using simulations, finding a preference for disordered membranes like the endoplasmic reticulum.

DOI 10.1016/j.bpj.2022.10.019

humanmechanistic / dynamical model

𝕏 PostBluesky