Paneth and Paneth-like cells undergoing necroptosis fuel intestinal epithelial cell proliferation following IFN-γ stimulation.
P. Nava, M. R. Encarnacion-Garcia, R. De la Torre-Baez, M. A. Hernandez-Cueto, L. A. Velazquez-Villegas, A. Candelario-Martinez, P. H. Horta-Lopez, A. Montoya-Garcia, G. A. Jaimes-Ortega, L. Lopez-Bailon, Z. Piedra-Quintero, G. Carrasco-Torres, M. De Ita, M. d. P. Figueroa-Corona, J. E. Munoz-Medina, , L. G. Noriega
This study shows IFN-γ stimulates intestinal epithelial cell proliferation via Paneth and Paneth-like cell degranulation, dependent on mTORC1 and necroptosis.
bioRxiv · May 13, 2023 · PreprintPhysiology