Aged insulin resistant macrophages reveal dysregulated cholesterol biosynthesis, a pro-inflammatory profile and reduced foam cell formation capacity
G. Chabrier, S. Hobson, N. Yuldasheva, M. T. Kearney, S. Schurmans, I. Pineda-Torra, M. C. Gage
This study investigates how insulin resistance in aged macrophages affects inflammation, cholesterol biosynthesis, and foam cell formation, finding pro-inflammatory changes and reduced foam cell capacity.
bioRxiv · Nov 9, 2018 · PreprintImmunology