Author

M. T. Kearney

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

D. J. Beech· 3 shared H. Viswambharan· 3 shared S. B. Wheatcroft· 3 shared C. G. Myers· 2 shared C. W. Fishwick· 2 shared K. Bridge· 2 shared K. J. Simmons· 2 shared L. Lunn· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

D. J. Beech

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Author profile →

5 papers

Recent·Most cited

Small molecule modulation of insulin receptor-insulin like growth factor-1 receptor heterodimers in human endothelial cells

C. G. Myers, H. Viswambharan, N. Haywood, K. Bridge, S. J. Turvey, T. Armstrong, L. Lunn, P. J. Meakin, E. M. Clavane, D. J. Beech, R. M. Cubbon, S. B. Wheatcroft, M. J. McPhillie, T. Issad, C. W. Fishwick, , K. J. Simmons

This paper identifies a small molecule that reduces IR:IGF-1R hybrid formation in human endothelial cells, increasing Akt phosphorylation and altering PI3-kinase signaling.

bioRxiv · Mar 11, 2024Cell Biology

A small molecule reveals role of insulin receptor-insulin like growth factor-1 receptor heterodimers

K. J. Simmons, C. G. Myers, H. Viswambharan, N. Haywood, K. Bridge, S. J. Turvey, T. Armstrong, L. Lunn, P. J. Meakin, E. Clavane, D. J. Beech, R. Cubbon, S. B. Wheatcroft, M. J. McPhillie, C. W. Fishwick, M. T. Kearney

The paper identifies a small molecule that inhibits insulin receptor-insulin-like growth factor-1 receptor heterodimers, revealing their distinct physiological role in endothelial cells.

bioRxiv · Dec 9, 2021 · PreprintCell Biology

Reduced insulin and IGF-1 signalling synergistically extend healthspan in male mice

A. M. N. Walker, N. T. Watt, N. Warmke, N. Y. Yuldasheva, M. Drozd, N. J. Haywood, A. Skromna, N. Makava, S. B. Wheatcroft, M. T. Kearney, R. M. Cubbon

This study shows that reducing both insulin and IGF-1 signaling in male mice synergistically extends healthspan, as evidenced by longer survival and preserved nesting behavior compared to single-gene knockouts.

bioRxiv · Mar 15, 2019 · PreprintCell Biology

Aged insulin resistant macrophages reveal dysregulated cholesterol biosynthesis, a pro-inflammatory profile and reduced foam cell formation capacity

G. Chabrier, S. Hobson, N. Yuldasheva, M. T. Kearney, S. Schurmans, I. Pineda-Torra, M. C. Gage

This study investigates how insulin resistance in aged macrophages affects inflammation, cholesterol biosynthesis, and foam cell formation, finding pro-inflammatory changes and reduced foam cell capacity.

bioRxiv · Nov 9, 2018 · PreprintImmunology

Piezo1 channel agonist mimics high glucose as a stimulator of insulin release

V. Deivasikamani, S. Dhayalan, R. Mughal, A. Visnagri, K. Cuthbertson, J. L. Scragg, T. S. Munsey, H. Viswambharan, R. Foster, A. Sivaprasadarao, M. T. Kearney, D. J. Beech, P. Sukumar

This study shows that Piezo1 agonist Yoda1 stimulates insulin release from beta-cells and pancreatic islets, suggesting Piezo1's role in cell swelling-induced insulin secretion.

bioRxiv · Oct 29, 2018Cell Biology