The mRNA cap 2'O methyltransferase CMTR1 regulates the expression of certain interferon-stimulated genes
G. D. Williams, N. S. Gokhale, D. L. Snider, S. M. Horner
This study shows that CMTR1, an ISG, promotes the protein expression of specific ISGs involved in the antiviral response by preventing IFIT1 from inhibiting translation of mRNAs lacking cap 2O methylation.
bioRxiv · Mar 5, 2020Immunology