Author

N. S. Gokhale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:metagenomics· 2 Research Focus:differential expression· 1

Frequent Co-Authors

S. M. Horner· 4 shared R. Savan· 3 shared J. L. Hyde· 2 shared M. Gale· 2 shared A. B. R. McIntyre· 1 shared A. E. L. Stone· 1 shared A. Forero· 1 shared A. M. Kell· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersImmunology

S. M. Horner

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Cellular RNA interacts with MAVS to promote antiviral signaling

N. S. Gokhale, K. Somfleth, M. G. Thompson, R. K. Sam, D. M. Marciniak, L. H. Chu, M. Park, S. Dvorkin, A. Oberst, S. M. Horner, S.-E. Ong, M. Gale, R. Savan

The paper shows that cellular RNA interacts with MAVS to scaffold signaling proteins and promote antiviral signaling by facilitating IRF3 phosphorylation.

bioRxiv · Sep 25, 2023 · PreprintImmunology

Structure-first identification of conserved RNA elements that regulate dengue virus genome architecture and replication.

M. A. Boerneke, N. S. Gokhale, S. M. Horner, K. M. Weeks

The paper identifies conserved RNA structures in dengue virus genomes that regulate replication and fitness, revealing their importance in viral function and potential as antiviral targets.

bioRxiv · Oct 10, 2022Biochemistry

Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome

B. V. Tsu, R. Agarwal, N. S. Gokhale, J. Kulsuptrakul, A. P. Ryan, L. K. Castro, C. M. Beierschmitt, E. A. Turcotte, E. J. Fay, R. E. Vance, J. L. Hyde, R. Savan, P. S. Mitchell, M. D. Daugherty

This study identifies CARD8 as a sensor for viral proteases, showing it activates inflammasomes in response to coronavirus 3CLpro and can be modulated by genetic variation.

bioRxiv · Sep 21, 2022Immunology

Endomembrane targeting of human OAS1 p46 augments antiviral activity

F. W. Soveg, J. Schwerk, N. S. Gokhale, K. Cerosaletti, J. R. Smith, E. Pairo-Castineira, A. M. Kell, A. Forero, S. A. Zaver, K. Esser-Nobis, J. Roby, T.-Y. Hsiang, S. Ozarkar, J. M. Clingan, E. T. McAnarney, , R. Savan

This study shows that the OAS1 p46 isoform, targeted to the endomembrane system, enhances antiviral activity against RNA viruses and is associated with COVID-19 severity.

bioRxiv · Apr 21, 2021Immunology

Post-Transcriptional Regulation of Antiviral Gene Expression by N6-Methyladenosine

M. J. McFadden, A. B. R. McIntyre, H. Mourelatos, N. S. Abell, N. S. Gokhale, H. Ipas, B. Xhemalce, C. E. Mason, S. M. Horner

This study identifies N6-methyladenosine (m6A) as a post-transcriptional regulator of IFN-stimulated gene (ISG) translation during the type I IFN response, enhancing antiviral activity.

bioRxiv · Aug 5, 2020Immunology

The mRNA cap 2'O methyltransferase CMTR1 regulates the expression of certain interferon-stimulated genes

G. D. Williams, N. S. Gokhale, D. L. Snider, S. M. Horner

This study shows that CMTR1, an ISG, promotes the protein expression of specific ISGs involved in the antiviral response by preventing IFIT1 from inhibiting translation of mRNAs lacking cap 2O methylation.

bioRxiv · Mar 5, 2020Immunology