Systematic development of peptide inhibitors targeting the CXCL12/HMGB1 interaction
J. Sgrignani, V. Cecchinato, E. M. A. Fassi, G. Dagostino, M. Garofalo, G. Danelon, G. Grazioso, M. Uguccioni, A. Cavalli
This study identifies a peptide inhibitor (HBP08) that disrupts the CXCL12/HMGB1 heterocomplex with high affinity, offering potential for treating chronic inflammatory diseases.
bioRxiv · Dec 18, 2019Biochemistry