A. Cavalli

Characterization of a novel humanized heavy chain antibody targeting endogenous retroviruses with anti-lymphoma activity

This study identifies HERV-K as a therapeutic target in DLBCL, develops a humanized nanobody with anti-lymphoma activity, and shows its potential through antibody-dependent cytotoxicity.

Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages

Engineered dimeric and secretory IgA1 neutralized Omicron variants with higher potency than parental IgG.

PI3Kδ activation, IL6 over-expression, and CD37 loss cause resistance to the targeting of CD37-positive lymphomas with the antibody-drug conjugate naratuximab emtansine

This paper identifies two resistance mechanisms to the CD37-targeting ADC naratuximab emtansine in lymphoma cell lines and suggests combination therapies to overcome resistance.

Mitochondrial DNA released by senescent cells triggers immunosuppression in cancer

This study shows that mtDNA released by senescent cells triggers immunosuppression via PMN-MDSCs, and inhibiting this pathway enhances therapy-induced senescence in cancer.

Novel structural insights on full-length human RAD52: Cryo-EM and beyond

This paper presents the Cryo-EM structure of full-length human RAD52 at 2.16 Å resolution, revealing its undecameric N-terminal ring and disordered C-terminal region, with implications for inhibitor development.

Metformin antiproliferative activity is exclusively mediated by the membrane functional expression of the Chloride Intracellular Channel 1 in glioblastoma stem cells

This study identifies tmCLIC1 as the specific metformin receptor in glioblastoma stem cells, showing that metformin's antiproliferative effect depends on its binding to tmCLIC1 and subsequent inhibition of mitochondrial respiration.

Myc controls IL-15-driven expansion and translational machinery of NK cells

This study shows that Myc is essential for NK cell development, expansion, and anticancer immunity by regulating translational machinery and IL-15 responses.

A first-in-class Wiskott-Aldrich syndrome protein (WASp) activator with anti-tumor activity in hematological cancers

This paper develops EG-011, a first-in-class WASp activator with anti-tumor activity in hematological cancers, including resistant models.

Anti-chemokine antibodies after SARS-CoV-2 infection correlate with favorable disease course

The paper finds that anti-chemokine antibodies after SARS-CoV-2 infection correlate with favorable disease outcomes and predict absence of long COVID symptoms.

RAD51 nuclear recruitment and inhibition towards innovative strategies against pancreatic cancer

This study investigates BRC4's role in inhibiting RAD51's nuclear recruitment and its effect on HR in pancreatic cancer cells, showing enhanced cisplatin cytotoxicity.

Systematic development of peptide inhibitors targeting the CXCL12/HMGB1 interaction

This study identifies a peptide inhibitor (HBP08) that disrupts the CXCL12/HMGB1 heterocomplex with high affinity, offering potential for treating chronic inflammatory diseases.

Oxidation state dependent conformational changes of HMGB1 regulates the formation of the CXCL12/HMGB1 heterocomplex

This study shows that the redox state of HMGB1 affects its conformation, enabling complex formation with CXCL12, which enhances leukocyte recruitment via CXCR4.