Author

M. Uguccioni

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

J. Sgrignani· 3 shared A. Cavalli· 2 shared E. M. A. Fassi· 2 shared G. Grazioso· 2 shared M. Garofalo· 2 shared V. Cecchinato· 2 shared A. A. Shanbhag· 1 shared A. Celoria· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

J. Sgrignani

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Human neutralizing antibodies to cold linear epitopes and to subdomain 1 of SARS-CoV-2

F. Bianchini, V. Crivelli, M. E. Abernathy, C. Guerra, M. Palus, J. Muri, H. Marcotte, A. Piralla, M. Pedotti, R. De, L. Simonelli, M. Matkovic, C. Toscano, M. Biggiogero, V. Calvaruso, , Ru

The paper identifies broadly cross-reactive neutralizing antibodies against SARS-CoV-2 variants using coldspot-guided antibody discovery.

bioRxiv · Nov 24, 2022 · PreprintImmunology

Systematic development of peptide inhibitors targeting the CXCL12/HMGB1 interaction

J. Sgrignani, V. Cecchinato, E. M. A. Fassi, G. Dagostino, M. Garofalo, G. Danelon, G. Grazioso, M. Uguccioni, A. Cavalli

This study identifies a peptide inhibitor (HBP08) that disrupts the CXCL12/HMGB1 heterocomplex with high affinity, offering potential for treating chronic inflammatory diseases.

bioRxiv · Dec 18, 2019Biochemistry

Oxidation state dependent conformational changes of HMGB1 regulates the formation of the CXCL12/HMGB1 heterocomplex

E. M. A. Fassi, J. Sgrignani, G. D'Agostino, V. Cecchinato, M. Garofalo, G. Grazioso, M. Uguccioni, A. Cavalli

This study shows that the redox state of HMGB1 affects its conformation, enabling complex formation with CXCL12, which enhances leukocyte recruitment via CXCR4.

bioRxiv · May 28, 2019Biochemistry