Blockade of redox second messengers inhibits JAK/STAT and MEK/ERK signaling sensitizing FLT3-mutant acute myeloid leukemia to targeted therapies
Z. P. Germon, J. R. Sillar, A. Mannan, R. J. Duchatel, D. Staudt, H. C. Murray, I. J. Findlay, E. R. Jackson, H. P. McEwen, A. M. Douglas, T. Mclachlan, J. E. Schjenken, D. A. Skerrett-Byrne, H. Huang, M. N. Melo-Braga, , M. D. Dun
This study identifies the Rac-NOX2 complex as a driver of redox signaling in FLT3-mutant AML, showing that inhibiting NOX2 reduces key signaling pathways and enhances response to FLT3 inhibitors.
bioRxiv · Mar 9, 2022 · PreprintCancer Biology