Author

A. K. Enjeti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Mannan· 2 shared C. de Bock· 2 shared H. C. Murray· 2 shared M. D. Dun· 2 shared N. M. Verrills· 2 shared A. H. Wei· 1 shared A. M. Douglas· 1 shared B. M. Harvey· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

A. Mannan

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2 papers

Recent·Most cited

Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for AML cell self-renewal.

D. R. Bond, S. M. Burnard, K. Uddipto, K. V. Hunt, B. M. Harvey, L. Steffens Reinhardt, C. Lawlor-O'Neill, E. A. Roper, S. Humphries, H. C. Murray, A. Mannan, M. D. Dun, C. de Bock, N. A. Bowden, A. K. Enjeti, , H. J. Lee

This study shows that hypomethylating agents induce epigenetic and transcriptional heterogeneity in AML cells, with some cells retaining methylation and showing increased self-renewal, and identifies statins as a potential co-treatment to enhance HMA efficacy.

bioRxiv · Jan 30, 2024Cancer Biology

Blockade of redox second messengers inhibits JAK/STAT and MEK/ERK signaling sensitizing FLT3-mutant acute myeloid leukemia to targeted therapies

Z. P. Germon, J. R. Sillar, A. Mannan, R. J. Duchatel, D. Staudt, H. C. Murray, I. J. Findlay, E. R. Jackson, H. P. McEwen, A. M. Douglas, T. Mclachlan, J. E. Schjenken, D. A. Skerrett-Byrne, H. Huang, M. N. Melo-Braga, , M. D. Dun

This study identifies the Rac-NOX2 complex as a driver of redox signaling in FLT3-mutant AML, showing that inhibiting NOX2 reduces key signaling pathways and enhances response to FLT3 inhibitors.

bioRxiv · Mar 9, 2022 · PreprintCancer Biology