Author

T. Mclachlan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. M. Douglas· 2 shared A. Mannan· 2 shared B. Nixon· 2 shared D. A. Skerrett-Byrne· 2 shared E. R. Jackson· 2 shared H. C. Murray· 2 shared H. P. McEwen· 2 shared I. J. Findlay· 2 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

A. M. Douglas

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

High-Throughput Global Phosphoproteomic Profiling Using Phospho Heavy-Labeled-Spiketide FAIMS Stepped-CV DDA (pHASED)

D. E. Staudt, H. C. Murray, D. A. Skerrett-Byrne, N. D. Smith, M. F. Jamaluddin, R. G. S. Kahl, R. J. Duchatel, Z. Germon, T. McLachlan, E. R. Jackson, I. J. Findlay, P. S. Kearney, A. Mannan, H. P. McEwen, A. M. Douglas, , M. D. Dun

This paper introduces a new phosphoproteomics protocol, pHASED, which reduces sample preparation time and increases phosphoproteomic coverage compared to traditional methods, revealing potential therapeutic targets in AML.

bioRxiv · Apr 22, 2022 · PreprintBiochemistry

Blockade of redox second messengers inhibits JAK/STAT and MEK/ERK signaling sensitizing FLT3-mutant acute myeloid leukemia to targeted therapies

Z. P. Germon, J. R. Sillar, A. Mannan, R. J. Duchatel, D. Staudt, H. C. Murray, I. J. Findlay, E. R. Jackson, H. P. McEwen, A. M. Douglas, T. Mclachlan, J. E. Schjenken, D. A. Skerrett-Byrne, H. Huang, M. N. Melo-Braga, , M. D. Dun

This study identifies the Rac-NOX2 complex as a driver of redox signaling in FLT3-mutant AML, showing that inhibiting NOX2 reduces key signaling pathways and enhances response to FLT3 inhibitors.

bioRxiv · Mar 9, 2022 · PreprintCancer Biology