IL-1β turnover by TRIP12 and AREL1 ubiquitin ligases and UBE2L3 limits inflammation
V. Mishra, A. Crespo-Puig, C. McCarthy, T. Masonou, I. Glegola-Madejska, A. Dejoux, G. Dow, M. J. G. Eldridge, L. H. Marinelli, M. Meng, S. Wang, D. J. Bennison, A. R. Shenoy
This study identifies UBE2L3, TRIP12, and AREL1 as ubiquitin ligases that regulate pro-IL-1β turnover, limiting inflammation by reducing precursor availability.
bioRxiv · Sep 14, 2022Immunology