ImmunologybioRxiv
IL-1β turnover by TRIP12 and AREL1 ubiquitin ligases and UBE2L3 limits inflammation
V. Mishra, A. Crespo-Puig, C. McCarthy…·A. R. Shenoy
This study identifies UBE2L3, TRIP12, and AREL1 as ubiquitin ligases that regulate pro-IL-1β turnover, limiting inflammation by reducing precursor availability.
DOI 10.1038/s41467-023-40054-x