V. Mishra

Improved synthesis and application of an alkyne-functionalized isoprenoid analogue to study the prenylomes of motor neurons, astrocytes and their stem cell progenitors

The paper improves the synthesis of C15AlkOPP and uses it to label and analyze prenylated proteins in motor neurons, astrocytes, and their stem cell progenitors, identifying 54, 50, and 84 prenylated proteins respectively.

Aminoglycoside heteroresistance in Enterobacter cloacae is driven by the cell envelope stress response.

This study identifies the CpxRA cell envelope stress response as the driver of aminoglycoside heteroresistance in E. cloacae, showing its role in transient resistance and MIC elevation.

AAV-mediated Delivery of Plakophilin-2a Arrests Progression of Arrhythmogenic Right Ventricular Cardiomyopathy in Murine Hearts: Preclinical Evidence Supporting Gene Therapy in Humans

This paper demonstrates that AAV-mediated delivery of PKP2a gene therapy arrests ARVC progression and prolongs survival in PKP2-deficient mice.

A High Fraction of Oral Bacteria in the Feces Indicates Gut Microbiota Depletion with Implications for Human Health

The paper investigates the association between oral bacteria in feces and gut microbiota depletion, supporting the Marker hypothesis over the Expansion hypothesis.

IL-1β turnover by TRIP12 and AREL1 ubiquitin ligases and UBE2L3 limits inflammation

This study identifies UBE2L3, TRIP12, and AREL1 as ubiquitin ligases that regulate pro-IL-1β turnover, limiting inflammation by reducing precursor availability.

Inter-subunit Crosstalk via PDZ Synergistically Governs Allosteric Activation of Proapoptotic HtrA2

This study investigates how PDZ domains in HtrA2 subunits synergistically regulate allosteric activation through inter-subunit crosstalk, revealing a model of cooperative energy landscape dynamics.

Molecular insights into the inhibition of plasmepsins by HIV-1 protease inhibitors: Implications for antimalarial drug discovery

This study investigates how HIV-1 protease inhibitors inhibit plasmepsins in Plasmodium falciparum, revealing structural insights that could guide the development of new antimalarial drugs.

Structures of plasmepsin X from P. falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme

The paper reports the crystal structure of PfPMX zymogen, revealing a novel inactivation mechanism and molecular basis for inhibitor binding in the mature enzyme.

Iron-dependent mutualism between Chlorella sorokiniana and Ralstonia pickettii forms the basis for a sustainable bioremediation system

This paper establishes a mutualistic relationship between Chlorella sorokiniana and Ralstonia pickettii to enhance iron bioavailability and azo dye degradation in bioremediation.

MicroRNA775 and target Galactosyltransferase (GALT9) module regulates recovery from submergence induced senescence by modulating SAGs in Arabidopsis thaliana

This study identifies miR775 and its target GALT9 as regulators of submergence-induced senescence recovery in Arabidopsis by modulating SAGs and ROS levels.

Control of Cucumber green mottle mosaic virus in commercial greenhouse production with agricultural disinfectants and resistant cucumber varieties

This paper evaluates strategies to control cucumber green mottle mosaic virus in greenhouses using disinfectants and resistant cucumber varieties, finding that specific cleaning methods and certain varieties reduce infection spread.

Assembly of a double-stranded RNA synthesizing complex: RNA-DEPENDENT RNA POLYMERASE 2 docks with NUCLEAR RNA POLYMERASE IV at the clamp domain

The paper identifies how RDR2 binds to the clamp domain of Pol IV to facilitate dsRNA synthesis for siRNA production in plants.

Reaction mechanisms of Pol IV, RDR2 and DCL3 drive RNA channeling in the siRNA-directed DNA methylation pathway

Absence of receptor guanylyl cyclase C enhances ileal damage and reduces cytokine and antimicrobial peptide production during oral Salmonella Typhimurium infection