Host-derived lipids from tuberculous pleurisy impair macrophage microbicidal-associated metabolic activity
J. L. Marin Franco, M. Genoula, D. Corral, G. Duette, M. Ferreyra, M. Maio, B. Dolotowicz, O. E. Aparicio-Trejo, E. Patino-Martinez, F. Fuentes, V. Soldan, E. J. Morana, D. Palmero, M. Ostrowski, P. Schierloh, , L. Balboa
This study shows that host-derived lipids from tuberculous pleurisy reduce glycolytic activity and impair HIF-1-mediated metabolic reprogramming in macrophages, promoting Mtb infection.
bioRxiv · Mar 23, 2020Immunology