C. Verollet

The immunosuppressive Tuberculosis-associated microenvironment inhibits viral replication and promotes HIV-1 latency in CD4+ T cells

This study shows that the TB-associated microenvironment suppresses HIV-1 replication and promotes latency in CD4+ T cells from HIV-1 patients.

The membrane-actin linkers ezrin, radixin, and moesin are dispensable for macrophage migration and cortex mechanics.

This study shows that ezrin, radixin, and moesin are not required for macrophage migration or actin cortex mechanics, challenging their universal importance in these processes.

Elevated glycolytic metabolism of monocytes limits the generation of HIF-1α-driven migratory dendritic cells in tuberculosis

This study shows that elevated glycolytic metabolism in monocytes during tuberculosis impairs their differentiation into migratory dendritic cells, limiting immune response.

Nanoscale architecture and coordination of actin cores within the sealing zone of human osteoclasts

This study uses advanced microscopy to reveal the nanoscale organization of actin cores in human osteoclast sealing zones, showing localized synchronization and coordination via actinin1 filaments.

Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

This study identifies Siglec-1 as a factor induced by TB-associated IFN-I that localizes on TNTs and promotes HIV-1 spread in macrophages.

Host-derived lipids from tuberculous pleurisy impair macrophage microbicidal-associated metabolic activity

This study shows that host-derived lipids from tuberculous pleurisy reduce glycolytic activity and impair HIF-1-mediated metabolic reprogramming in macrophages, promoting Mtb infection.

Primary myeloid cell proteomics and transcriptomics: importance of β tubulin isotypes for osteoclast function.

This study provides proteomic and transcriptomic data of primary myeloid cells, identifying Tubb6 as a key regulator of osteoclast function through podosome organization and bone resorption.

HIV-1-infected human macrophages, by secreting RANKL, contribute to enhanced osteoclastogenesis

This study shows HIV-1-infected macrophages secrete RANKL, promoting osteoclast precursor migration and contributing to bone degradation in HIV-1 patients.

Mycobacterium tuberculosis Modulates the Metabolism of Alternatively Activated Macrophages to Promote Foam Cell Formation and Intracellular Survival

This study shows that Mtb modulates macrophage metabolism to promote foam cell formation and survival by altering lipid metabolism and FAO pathways.