A patient-designed tissue-engineered model of the infiltrative glioblastoma microenvironment
R. C. Cornelison, J. X. Yuan, K. M. Tate, A. Petrosky, G. F. Beeghly, M. Bloomfield, S. R. Schwager, A. L. Berr, D. Cimini, F. F. Bafakih, J. W. Mandell, B. W. Purow, B. J. Horton, J. Munson
This study develops a patient-derived 3D tissue-engineered model of glioblastoma to assess invasion, proliferation, and stemness in response to fluid flow and glial interactions, finding CD71 expression better predicts drug efficacy than viability.
bioRxiv · Oct 2, 2020Bioengineering