Author

B. J. Horton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. L. Berr· 1 shared A. Petrosky· 1 shared A. Sharma· 1 shared B. W. Purow· 1 shared C. E. Chalfant· 1 shared D. Cimini· 1 shared D. F. Claxton· 1 shared D. J. Feith· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBioengineering

A. L. Berr

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Author profile →

2 papers

Recent·Most cited

Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia

J. Ung, S.-F. Tan, T. E. Fox, J. J. Shaw, M. Taori, B. J. Horton, U. Golla, A. Sharma, Z. M. Szulc, H.-G. Wang, C. E. Chalfant, M. C. Cabot, D. F. Claxton, T. P. Loughran, D. J. Feith

This study evaluates the anti-leukemic effects of LCL-805, an acid ceramidase inhibitor, in AML cell lines and patient samples, showing it promotes iron-dependent cell death by antagonizing Akt signaling.

bioRxiv · Oct 21, 2023Cancer Biology

A patient-designed tissue-engineered model of the infiltrative glioblastoma microenvironment

R. C. Cornelison, J. X. Yuan, K. M. Tate, A. Petrosky, G. F. Beeghly, M. Bloomfield, S. R. Schwager, A. L. Berr, D. Cimini, F. F. Bafakih, J. W. Mandell, B. W. Purow, B. J. Horton, J. Munson

This study develops a patient-derived 3D tissue-engineered model of glioblastoma to assess invasion, proliferation, and stemness in response to fluid flow and glial interactions, finding CD71 expression better predicts drug efficacy than viability.

bioRxiv · Oct 2, 2020Bioengineering