Precision targeting of the Plasminogen Activator Inhibitor-1 mechanism increases efficacy of fibrinolytic therapy in empyema.
G. Florova, R. A. Girard, A. O. Azghani, K. Sarva, A. Buchanan, S. Karandashova, C. J. DeVera, D. Hill, M. Chamiso, K. Koenig, D. B. Cines, S. Idell, A. A. Komissarov
The paper demonstrates that targeting PAI-1 with DSP reduces the required dose of tPA/uPA in empyema treatment without bleeding complications in rabbit models.
bioRxiv · Oct 5, 2020Biochemistry