Author

D. B. Cines

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. Poncz· 4 shared A. Sarkar· 2 shared L. Rauova· 2 shared M. A. Kowalska· 2 shared S. V. Zaitsev· 2 shared V. Stepanova· 2 shared A. A. Komissarov· 1 shared A. Buchanan· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersCell Biology

M. Poncz

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Packaging of supplemented urokinase into naked alpha-granules of in vitro-grown megakaryocytes for targeted therapeutic delivery

M. Poncz, S. V. Zaitsev, H. Ahn, M. A. Kowalska, K. Bdeir, R. M. Camire, D. B. Cines, V. Stepanova

The paper demonstrates that in vitro-grown megakaryocytes can store exogenous uPA in alpha-granules, which can be used to generate anti-thrombotic human platelets that lyse nascent thrombi in a mouse model.

bioRxiv · Dec 5, 2023 · PreprintCell Biology

PAI-1 Deficiency Drives Pulmonary Vascular Smooth Muscle Remodeling and Pulmonary Hy-pertension

T. V. Kudryashova, S. V. Zaitsev, L. Jiang, B. J. Buckley, J. P. McGuckin, D. Goncharov, I. Zhyvylo, D. Lin, G. Newcomb, B. Piper, S. Bogamuwa, A. Saiyed, L. Teos, M. Ranson, P. Wolters, , V. Stepanova

This study shows PAI-1 deficiency in PASMC promotes pulmonary vascular remodeling and hypertension by enhancing uPA activity, leading to cell proliferation and reduced apoptosis.

bioRxiv · Sep 21, 2023Cell Biology

Neutrophil extracellular trap stabilization by platelet factor 4 reduces thrombogenicity and endothelial cell injury

A. T. Ngo, A. Sarkar, I. Yarovoi, N. Levine, V. Bochenek, G. Zhao, L. Rauova, M. A. Kowalska, K. Eckart, N. Mangalmurti, A. Rux, D. B. Cines, M. Poncz, K. Gollomp

This study shows that stabilizing neutrophil extracellular traps (NETs) with platelet factor 4 reduces thrombogenicity and endothelial cell injury in sepsis.

bioRxiv · Jan 9, 2023 · PreprintCell Biology

Prevention of thrombocytopenia and thrombosis in heparin-induced thrombocytopenia (HIT) using deglycosylated KKO: A novel therapeutic?

A. Sarkar, S. Khandelwal, H. Kim, Y. Gruel, J. Rollin, G. D. Wool, G. M. Arepally, D. B. Cines, L. Rauova, M. Poncz

This paper demonstrates that deglycosylated KKO (DGKKO) can prevent and reverse thrombocytopenia and thrombosis in a HIT murine model.

bioRxiv · Oct 19, 2022 · PreprintCell Biology

Precision targeting of the Plasminogen Activator Inhibitor-1 mechanism increases efficacy of fibrinolytic therapy in empyema.

G. Florova, R. A. Girard, A. O. Azghani, K. Sarva, A. Buchanan, S. Karandashova, C. J. DeVera, D. Hill, M. Chamiso, K. Koenig, D. B. Cines, S. Idell, A. A. Komissarov

The paper demonstrates that targeting PAI-1 with DSP reduces the required dose of tPA/uPA in empyema treatment without bleeding complications in rabbit models.

bioRxiv · Oct 5, 2020Biochemistry