Author

G. Grueber

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Microbiology· 1

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Approach:experimental assay· 1

Frequent Co-Authors

E. J. Rubin· 1 shared J. Sarathy· 1 shared J. Shin· 1 shared J. Zhu· 1 shared M. Gengenbacher· 1 shared M. Yee· 1 shared O. Kandror· 1 shared P. Gopal· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperMicrobiology

E. J. Rubin

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1 paper

Recent·Most cited

Pyrazinamide triggers degradation of its target aspartate decarboxylase

P. Gopal, J. Sarathy, M. Yee, P. Ragunathan, J. Shin, S. Bhushan, J. Zhu, T. Akopian, O. Kandror, T. K. Lim, M. Gengenbacher, Q. Lin, E. J. Rubin, G. Grueber, T. Dick

This paper shows that pyrazinamide's active form, POA, triggers degradation of its target enzyme PanD via the ClpC1-ClpP protease, rather than inhibiting it directly.

Nature Communications · Apr 3, 2020Peer-reviewedMicrobiology