S. Bhushan

Depletion of CX3CR1+ macrophages results in disrupted functionality and immune surveillance within epididymis and testis

This study shows that CX3CR1+ macrophages are essential for maintaining immune balance and epithelial integrity in the epididymis and testis, with their depletion leading to immune dysfunction and fertility issues.

Iron regulatory proteins 1 and 2 have opposing roles in regulating inflammation in bacterial orchitis

This study shows that IRP1 deletion reduces inflammation and testicular damage in UPEC-induced orchitis, while IRP2 deletion increases inflammation.

Streptomycin and Pyridomycin drug molecules provide the most potential inhibitors against Rv3871 to cure Tuberculosis

This paper identifies streptomycin and pyridomycin as potential inhibitors of Rv3871, an ATPase involved in ESAT-6/CFP-10 secretion in Mycobacterium tuberculosis, aiming to treat tuberculosis.

The regional distribution of resident immune cells shapes distinct immunological environments along the murine epididymis

The paper identifies region-specific immune cell subsets in the murine epididymis using scRNA-seq, revealing distinct immunological environments along the duct.

Pyrazinamide triggers degradation of its target aspartate decarboxylase

This paper shows that pyrazinamide's active form, POA, triggers degradation of its target enzyme PanD via the ClpC1-ClpP protease, rather than inhibiting it directly.