Author

T. Akopian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

E. J. Rubin· 2 shared J. Zhu· 2 shared O. Kandror· 2 shared G. Grueber· 1 shared H. I. Won· 1 shared I. D. Wolf· 1 shared J. Sarathy· 1 shared J. Shin· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMicrobiology

E. J. Rubin

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2 papers

Recent·Most cited

Chemically-induced targeted protein degradation in mycobacteria uncovers antibacterial effects and potentiates antibiotic efficacy

H. I. Won, J. Zhu, O. Kandror, T. Akopian, I. D. Wolf, M. C. Chao, M. Waldor, E. J. Rubin

This study uses a genetic system to screen essential proteins in Mycobacterium smegmatis, identifying labile targets for PROTACs and showing their potential to enhance antibiotic efficacy.

bioRxiv · Feb 14, 2023Microbiology

Pyrazinamide triggers degradation of its target aspartate decarboxylase

P. Gopal, J. Sarathy, M. Yee, P. Ragunathan, J. Shin, S. Bhushan, J. Zhu, T. Akopian, O. Kandror, T. K. Lim, M. Gengenbacher, Q. Lin, E. J. Rubin, G. Grueber, T. Dick

This paper shows that pyrazinamide's active form, POA, triggers degradation of its target enzyme PanD via the ClpC1-ClpP protease, rather than inhibiting it directly.

Nature Communications · Apr 3, 2020Peer-reviewedMicrobiology