Author

G. Henderson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1

Frequent Co-Authors

E. Kelly· 2 shared K. J. Sutcliffe· 1 shared R. A. Corey· 1 shared R. B. Sessions· 1 shared R. Hill· 1 shared R. Santhakumar· 1 shared S. J. Charlton· 1 shared W. L. Dewey· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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2 shared papersPharmacology & Toxicology

E. Kelly

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2 papers

Recent·Most cited

Fentanyl binds to the mu-opioid receptor via the lipid membrane and transmembrane helices

K. J. Sutcliffe, R. A. Corey, S. J. Charlton, R. B. Sessions, G. Henderson, E. Kelly

This study identifies a novel binding mechanism of fentanyl to the mu-opioid receptor involving membrane partitioning and transmembrane helix diffusion, explaining its high potency and resistance to naloxone.

bioRxiv · Feb 4, 2021 · PreprintPharmacology & Toxicology

Fentanyl depression of respiration: comparison with heroin and morphine

R. Hill, R. Santhakumar, W. L. Dewey, E. Kelly, G. Henderson

This study compares how fentanyl, heroin, and morphine depress respiration in mice, finding that fentanyl's rapid onset, increased muscle stiffness, and reduced naloxone reversal contribute to its higher lethality.

bioRxiv · Jun 6, 2019Pharmacology & Toxicology