Author

S. J. Charlton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

D. A. Sykes· 1 shared D. B. Veprintsev· 1 shared E. Kelly· 1 shared G. Henderson· 1 shared J. Reilly· 1 shared K. J. Sutcliffe· 1 shared M. Jimenez Roses· 1 shared R. A. Corey· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperPharmacology & Toxicology

D. A. Sykes

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2 papers

Recent·Most cited

Exploring the kinetic selectivity of drugs targeting the β1-adrenoceptor

D. A. Sykes, M. Jimenez Roses, J. Reilly, R. A. Fairhurst, S. J. Charlton, D. B. Veprintsev

This study investigates the kinetic selectivity of drugs targeting the β1-adrenoceptor, finding that hydrophobic interactions dominate ligand binding kinetics over combined polar and hydrophobic interactions.

bioRxiv · Aug 31, 2021Pharmacology & Toxicology

Fentanyl binds to the mu-opioid receptor via the lipid membrane and transmembrane helices

K. J. Sutcliffe, R. A. Corey, S. J. Charlton, R. B. Sessions, G. Henderson, E. Kelly

This study identifies a novel binding mechanism of fentanyl to the mu-opioid receptor involving membrane partitioning and transmembrane helix diffusion, explaining its high potency and resistance to naloxone.

bioRxiv · Feb 4, 2021 · PreprintPharmacology & Toxicology