R. B. Sessions

Structural and temporal basis for agonism in the α4β2 nicotinic acetylcholine receptor

This study uses molecular dynamics simulations to analyze how full and partial agonists induce different conformational changes in the α4β2 nicotinic acetylcholine receptor, affecting signal propagation.

Understanding p300-transcription factor interactions using sequence variation and hybridization

The paper investigates HIF-1 sequence variation tolerance using biochemical assays, showing that sequence changes are tolerated through disordered binding interactions.

Identification and Validation of Novel Microtubule Suppressors with an Imidazopyridine Scaffold through Structure Based Virtual Screening and Docking.

This paper identifies and validates a novel imidazopyridine scaffold as a microtubule inhibitor through virtual screening and docking, showing antiproliferative and apoptotic effects in cancer cells.

Multi-modal adaptor-clathrin contacts drive coated vesicleassembly

This study identifies multi-modal adaptor-clathrin interactions essential for coated vesicle assembly, revealing two critical binding sites on AP2's β2 subunit.

Fentanyl binds to the mu-opioid receptor via the lipid membrane and transmembrane helices

This study identifies a novel binding mechanism of fentanyl to the mu-opioid receptor involving membrane partitioning and transmembrane helix diffusion, explaining its high potency and resistance to naloxone.

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

This study identifies STARD10 as a phosphoinositide binding protein that regulates insulin granule biogenesis in beta-cells by affecting phosphatidylinositol levels and proinsulin processing.

Brazilin Removes Toxic alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium

This paper shows Brazilin inhibits alpha-synuclein fibril formation and reduces toxicity in Parkinson's disease by altering conformational equilibrium.

Biophysical characterization of the ETV6 PNT domain polymerization interfaces

This study characterizes the biophysical properties of the ETV6 PNT domain polymerization interfaces to identify potential drug targets for inhibiting its self-association.

A Multi-pronged Screening Approach Targeting Inhibition of ETV6 PNT Domain Polymerization

This study develops experimental and computational assays to identify small molecule inhibitors of ETV6 PNT domain polymerization, finding no direct binders but gaining insights for future therapeutic development.

Simulations support the interaction of the SARS-CoV-2 spike protein with nicotinic acetylcholine receptors

The paper uses molecular simulations to show that the SARS-CoV-2 spike protein's Y674-R685 loop binds to nicotinic acetylcholine receptors, with specific interactions and conformational changes observed across different receptor subtypes.

Neuropilin-1 is a host factor for SARS-CoV-2 infection

This study shows that SARS-CoV-2's S1 protein binds to NRP1 via the CendR motif, enhancing infection and identifying NRP1 as a therapeutic target.

Nitrative signaling into cardiac lactate dehydrogenase Trp324 modulates active site loop mobility and activity under metabolic stress

This study identifies Trp324 nitration in lactate dehydrogenase as a physiological signaling mechanism modulating enzyme activity under metabolic stress.