G. K. Goddard

Generation of anisotropic strain dysregulates wild-type cell division at the interface between host and oncogenic tissue

This study shows that kRasV12 oncogene-expressing clusters induce anisotropic strain in host tissue, increasing cell division and altering division orientation, which can be reversed by reducing actomyosin contractility.

Decoupling the roles of cell shape and mechanical stress in orienting and cueing epithelial mitosis

This study decouples the roles of cell shape and mechanical stress in epithelial mitosis orientation and rate using Xenopus laevis tissue.